Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199184 | 0.82 | KMT2A (0.53) | KMT2ATP53USP2KDM4ETSHR | |
| SCHEMBL4210419 | 0.78 | KMT2A (0.62) | KMT2ATP53USP2KDM4EMEN1 | |
| SCHEMBL4581826 | 0.78 | KMT2A (0.62) | KMT2ATP53USP2TSHRMEN1 | |
| SCHEMBL4679461 | 0.76 | POLB (0.72) | KMT2ATP53USP2TSHRALDH1A1 | |
| SCHEMBL4581188 | 0.76 | TP53 (0.62) | KMT2ATP53USP2TSHRMEN1 | |
| SCHEMBL15825106 | 0.76 | KMT2A (0.71) | KMT2ATP53USP2MEN1MAPT | |
| SCHEMBL4211625 | 0.76 | USP2 (0.62) | KMT2ATP53USP2KDM4ETSHR | |
| SCHEMBL4687162 | 0.75 | TP53 (0.57) | KMT2ATP53USP2KDM4EMEN1 | |
| SCHEMBL4687156 | 0.74 | KMT2A (0.57) | KMT2ATP53USP2MEN1RAB9A | |
| SCHEMBL15333872 | 0.74 | PARP1 (0.51) | TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663204-A4 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-08-13 | — | — | EP | claimed |
| JP-2007504160-A | — | — | 2007-03-01 | — | — | JP | claimed |
| EP-1663204-A2 | C-KIT MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005020921-A2 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-03-10 | — | — | WO | claimed |