Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5112323 | 0.95 | SLC6A2 (0.41) | PGRCYP2D6CYP2C9USP30SLC6A2 | |
| SCHEMBL4479507 | 0.87 | SLC6A2 (0.48) | PGRCYP2D6CYP2C9SLC6A2SLC6A4 | |
| SCHEMBL5994302 | 0.84 | SLC6A2 (0.56) | PGRCYP2D6CYP2C9SLC6A2SLC6A4 | |
| SCHEMBL4690064 | 0.83 | SLC6A2 (0.53) | PGRCYP2D6CYP2C9USP30SLC6A2 | |
| SCHEMBL5440605 | 0.82 | SLC6A2 (0.47) | CYP2D6SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL5996937 | 0.79 | SLC6A2 (0.57) | SLC6A2SLC6A4MEN1KMT2ASLC6A3 | |
| SCHEMBL5995606 | 0.78 | SLC6A2 (0.51) | SLC6A2SLC6A4JAK2JAK1MEN1 | |
| SCHEMBL5670810 | 0.77 | SLC6A2 (0.53) | PGRCYP2D6CYP2C9USP30SLC6A2 | |
| SCHEMBL27661559 | 0.77 | SLC6A2 (0.53) | PGRCYP2D6CYP2C9USP30SLC6A2 | |
| SCHEMBL5993914 | 0.76 | SLC6A2 (0.59) | SLC6A2SLC6A4MEN1KMT2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-B1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-01-09 | — | — | EP | disclosed |