Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497702 | 0.87 | SLC6A2 (0.60) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL5996937 | 0.86 | SLC6A2 (0.57) | SLC6A2SLC6A4GPR119MEN1KMT2A | |
| SCHEMBL5996956 | 0.85 | SLC6A2 (0.58) | SLC6A2SLC6A4GPR119MEN1KMT2A | |
| SCHEMBL5995606 | 0.83 | SLC6A2 (0.51) | SLC6A2SLC6A4JAK2JAK1GPR119 | |
| SCHEMBL4687364 | 0.83 | PGR (0.43) | SLC6A2SLC6A4USP30PGRCYP2D6 | |
| SCHEMBL5994302 | 0.82 | SLC6A2 (0.56) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL27661559 | 0.82 | SLC6A2 (0.53) | SLC6A2SLC6A4USP30PGRCYP2D6 | |
| SCHEMBL5670810 | 0.82 | SLC6A2 (0.53) | SLC6A2SLC6A4USP30PGRCYP2D6 | |
| SCHEMBL5993914 | 0.81 | SLC6A2 (0.59) | SLC6A2SLC6A4GPR119MEN1KMT2A | |
| SCHEMBL5996568 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A4USP30PGRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-B1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-01-09 | — | — | EP | disclosed |