Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687860 | 0.92 | MRGPRX4 (0.46) | MAPK1TP53L3MBTL1THRATHRB | |
| SCHEMBL18077305 | 0.86 | NPC1 (0.55) | MAPK1TP53L3MBTL1THRATHRB | |
| SCHEMBL25781022 | 0.85 | THRA (0.50) | MAPK1THRATHRBMRGPRX4MAPT | |
| SCHEMBL25780651 | 0.85 | THRA (0.50) | MAPK1THRATHRBMRGPRX4MAPT | |
| SCHEMBL7783936 | 0.82 | SLC6A4 (0.43) | MAPK1THRATHRBMRGPRX4MAPT | |
| SCHEMBL4687532 | 0.81 | MAPK1 (0.48) | MAPK1TP53THRATHRBSLC6A2 | |
| SCHEMBL4464186 | 0.81 | MAPK1 (0.67) | MAPK1TP53MAPTSLC6A2SLC6A4 | |
| SCHEMBL15514846 | 0.79 | TSHR (0.47) | MAPK1SLC6A2SLC6A3CHEK2TSHR | |
| SCHEMBL4688980 | 0.78 | CYP1A2 (0.44) | MAPK1MRGPRX4MAPTSLC6A2SLC6A4 | |
| SCHEMBL4688976 | 0.78 | CYP1A2 (0.44) | MAPK1MRGPRX4MAPTSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805163-B1 | 1,1A,5,5A-TETRAHYDRO-3-THIA-CYCLOPROPA[A]PENTALENES: TRICYCLIC THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-01 | — | — | EP | claimed |