Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3166277 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL16269143 | 0.76 | CYP2D6 (0.49) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL15859936 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1ATMKMT2APOLB | |
| SCHEMBL4488404 | 0.74 | KDM4E (0.56) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL29716462 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL15859935 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1ATMKMT2AMAPT | |
| SCHEMBL21101334 | 0.71 | ALDH1A1 (0.56) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL15859937 | 0.71 | KDM4E (0.63) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL6944191 | 0.71 | KDM4E (0.63) | KDM4EALDH1A1ATMSIGMAR1KMT2A | |
| SCHEMBL24529820 | 0.71 | DRD4 (0.53) | SIGMAR1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-B1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-01-09 | — | — | EP | disclosed |