Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.44 |
| ▸ | DRD3 | P35462 | 10/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4683948 | 1.00 | DRD2 (0.44) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL4687249 | 0.79 | DRD3 (0.48) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL4688234 | 0.79 | DRD3 (0.48) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL10509406 | 0.72 | DRD2 (0.52) | DRD2DRD3DRD4KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL10671440 | 0.71 | DRD2 (0.51) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL4686705 | 0.70 | DRD2 (0.50) | DRD2DRD3DRD4OPRM1KCNH2 | |
| SCHEMBL4683950 | 0.70 | DRD2 (0.50) | DRD2DRD3DRD4OPRM1KCNH2 | |
| SCHEMBL10977567 | 0.70 | DRD2 (0.49) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL5231526 | 0.69 | DRD2 (0.60) | DRD2DRD3DRD4ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL11062974 | 0.69 | DRD2 (0.48) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753763-B1 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PFIZER LTD (GB) | 2008-08-13 | — | — | EP | claimed |