Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499226 | 0.86 | HTR2C (0.46) | TP53LMNAMAPTTHRBHTR2C | |
| SCHEMBL6219432 | 0.76 | HTR2C (0.44) | HTR2CADRB2ADRA2AAXLHRH1 | |
| SCHEMBL6220944 | 0.76 | HRH4 (0.54) | TP53LMNATHRBHTR2CADRB2 | |
| SCHEMBL4499993 | 0.74 | MAPT (0.54) | TP53LMNAMAPTTHRBHTR2C | |
| SCHEMBL1759343 | 0.74 | MAPT (0.54) | TP53LMNAMAPTTHRBHTR2C | |
| SCHEMBL5767981 | 0.71 | KDR (0.47) | HTR2C | |
| SCHEMBL2710036 | 0.71 | HTT (0.58) | MAPTHTR2C | |
| SCHEMBL2709277 | 0.70 | NCF1 (0.54) | — | |
| Hydrochloric Acid SCHEMBL1963879 | 0.70 | KDR (0.46) | HTR2C | |
| SCHEMBL2709881 | 0.69 | CYP1A2 (0.46) | TP53LMNAMAPTHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572698-B1 | 3-SUBSTITUTED 3,4-DIHYDRO-THIENO¬2,3-D PYRIMIDINE-4-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2008-07-02 | — | — | EP | disclosed |