Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690208 | 1.00 | KMT2A (0.51) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL3534536 | 0.91 | KMT2A (0.48) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL8424307 | 0.83 | HTT (0.56) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL3568957 | 0.82 | CA12 (0.42) | KMT2AALDH1A1MEN1RAB9AMAPT | |
| SCHEMBL4635694 | 0.80 | POLB (0.51) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL4635689 | 0.80 | POLB (0.51) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL4691091 | 0.79 | KMT2A (0.49) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL27716526 | 0.78 | HTT (0.58) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL4691085 | 0.77 | KMT2A (0.49) | KMT2AATMALDH1A1HTTPOLB | |
| SCHEMBL28779524 | 0.76 | ALDH1A1 (0.57) | KMT2AALDH1A1MEN1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973876-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | Wyeth (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007084841-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | WYETH (US) | 2007-07-26 | — | — | WO | disclosed |