Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 1.00 |
| ▸ | FLT1 | P17948 | 7/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 15/20 | 0.65 |
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383894 | 0.87 | FGFR1 (0.77) | FGFR1FLT1PDGFRBKDR | |
| SCHEMBL3381734 | 0.85 | FGFR1 (0.74) | FGFR1FLT1PDGFRBKDRCHEK1 | |
| SCHEMBL3381227 | 0.81 | FGFR1 (0.85) | FGFR1FLT1PDGFRBKDR | |
| SCHEMBL13042382 | 0.79 | FGFR1 (0.66) | FGFR1FLT1PDGFRBKDRPARP1 | |
| SCHEMBL17433339 | 0.79 | FGFR1 (1.00) | FGFR1FLT1PDGFRBKDRCHEK1 | |
| SCHEMBL3381338 | 0.78 | FGFR1 (0.86) | FGFR1FLT1PDGFRBKDR | |
| SCHEMBL3381059 | 0.77 | FGFR1 (1.00) | FGFR1FLT1PDGFRBKDRCHEK1 | |
| SCHEMBL3379167 | 0.77 | FGFR1 (0.72) | FGFR1FLT1PDGFRBKDRCHEK1 | |
| SCHEMBL3380939 | 0.76 | FGFR1 (0.62) | FGFR1FLT1PDGFRBKDRCHEK1 | |
| SCHEMBL3381294 | 0.74 | FGFR1 (0.86) | FGFR1FLT1PDGFRBKDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650203-B1 | Process of preparation of benzimidazol-2-yl quinolinone derivatives | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-02-20 | — | — | EP | disclosed |