Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692808 | 0.92 | MAPT (0.48) | KMT2ATP53MAPTLMNA | |
| SCHEMBL4690373 | 0.87 | TSHR (0.41) | KMT2ATSHRTP53MAPTLMNA | |
| SCHEMBL4694624 | 0.85 | POLB (0.44) | TSHRTP53MAPTLMNA | |
| SCHEMBL4691661 | 0.84 | MAPT (0.45) | TP53MAPT | |
| SCHEMBL4693812 | 0.82 | LMNA (0.48) | KMT2ATSHRTP53MAPTLMNA | |
| SCHEMBL4695934 | 0.81 | HCRTR1 (0.47) | KMT2ATSHRTP53MAPTMEN1 | |
| SCHEMBL4695747 | 0.81 | NR1H4 (0.47) | KMT2ATP53MAPTLMNA | |
| SCHEMBL4690733 | 0.81 | HCRTR1 (0.46) | KMT2ATP53MAPTMEN1USP2 | |
| SCHEMBL4694331 | 0.80 | TP53 (0.47) | KMT2ATSHRTP53MAPTLMNA | |
| SCHEMBL4690401 | 0.80 | TP53 (0.47) | KMT2ATSHRTP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |