Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.64 |
| ▸ | KDR | P35968 | 9/20 | 0.64 |
| ▸ | EGFR | P00533 | 7/20 | 0.63 |
| ▸ | BRAF | P15056 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | KIF5B | P33176 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | LTK | P29376 | 1/20 | 0.60 |
| ▸ | TTK | P33981 | 1/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689817 | 1.00 | SRC (0.64) | SRCKDREGFRBRAFRET | |
| SCHEMBL4693023 | 0.96 | RET (0.61) | SRCKDREGFRBRAFRET | |
| SCHEMBL4686384 | 0.91 | KDR (0.61) | SRCKDREGFRRETLCK | |
| SCHEMBL4689828 | 0.88 | RET (0.60) | KDREGFRRETKIF5B | |
| SCHEMBL4687659 | 0.87 | SRC (0.58) | SRCKDREGFRRETKIF5B | |
| SCHEMBL4687883 | 0.87 | EGFR (0.65) | SRCKDREGFRRETAURKA | |
| SCHEMBL4686900 | 0.87 | KDR (0.65) | SRCKDREGFRRET | |
| SCHEMBL4687801 | 0.83 | RET (0.66) | SRCKDREGFRRETKIF5B | |
| SCHEMBL5828725 | 0.83 | FLT1 (0.62) | SRCKDREGFRBRAFRET | |
| SCHEMBL5832489 | 0.83 | FLT1 (0.62) | SRCKDREGFRBRAFRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |