Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 3/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 6/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 11/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | KIF5B | P33176 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | BUB1 | O43683 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828725 | 1.00 | FLT1 (0.62) | FLT1FGFR1EGFRFBP1KDR | |
| SCHEMBL4689960 | 0.97 | FLT1 (0.59) | FLT1FGFR1EGFRFBP1KDR | |
| SCHEMBL4689400 | 0.97 | FLT1 (0.59) | FLT1FGFR1EGFRFBP1KDR | |
| SCHEMBL4689455 | 0.87 | EGFR (0.58) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL4689828 | 0.86 | RET (0.60) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL4690929 | 0.85 | EGFR (0.60) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL4689353 | 0.85 | KDR (0.55) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL4693023 | 0.84 | RET (0.61) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL4689817 | 0.83 | SRC (0.64) | EGFRKDRRETKIF5BALDH1A1 | |
| SCHEMBL4690799 | 0.83 | SRC (0.64) | EGFRKDRRETKIF5BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |