Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 4/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 10/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
| ▸ | FLT4 | P35916 | 5/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424669 | 0.87 | KDR (0.56) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL26069392 | 0.84 | PDE4A (0.49) | MCHR1CHEK1PDPK1 | |
| SCHEMBL4689340 | 0.81 | EPHA2 (0.57) | ENPP1PDE10AKDREPHA2EPHB4 | |
| SCHEMBL4417734 | 0.81 | EGFR (0.61) | KDREPHA2EPHB4ERBB2IRAK4 | |
| SCHEMBL4689911 | 0.80 | EPHA2 (0.61) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL16760417 | 0.79 | ENPP1 (0.61) | ENPP1PDE10AKDREPHA2EPHB4 | |
| SCHEMBL4687739 | 0.79 | EGFR (0.54) | ENPP1PDE10AKDREPHA2EPHB4 | |
| SCHEMBL4691126 | 0.79 | EPHA2 (0.58) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL4687074 | 0.79 | KDR (0.60) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL4688706 | 0.77 | MEN1 (0.69) | KDREPHA2EPHB4ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |