Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 18/20 | 0.58 |
| ▸ | KDR | P35968 | 12/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689911 | 0.97 | EPHA2 (0.61) | EPHA2KDRRETKIF5BEPHB4 | |
| SCHEMBL16760347 | 0.83 | EPHA2 (0.67) | EPHA2KDRRETKIF5BEPHB4 | |
| SCHEMBL26069947 | 0.81 | EPHA2 (0.50) | EPHA2KDRRETKIF5B | |
| SCHEMBL4424669 | 0.81 | KDR (0.56) | EPHA2KDRRETKIF5BEPHB4 | |
| SCHEMBL5648497 | 0.79 | EPHA2 (0.73) | EPHA2KDRRETKIF5BEPHB4 | |
| SCHEMBL4690822 | 0.79 | ENPP1 (0.47) | EPHA2KDREPHB4ERBB2EGFR | |
| SCHEMBL4689349 | 0.78 | MEN1 (0.68) | EPHA2KDRRETKIF5BEPHB4 | |
| SCHEMBL907202 | 0.77 | EPHA2 (0.95) | EPHA2KDREPHB4ERBB2EGFR | |
| SCHEMBL4689472 | 0.77 | EPHB4 (0.43) | EPHA2KDREPHB4ERBB2EGFR | |
| SCHEMBL6775063 | 0.77 | ABL1 (0.52) | EPHA2KDREPHB4ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |