Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 5/20 | 0.48 |
| ▸ | KIF5B | P33176 | 5/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023047 | 0.95 | TRPA1 (0.62) | TRPA1KDREGFRLCKFGFR1 | |
| Trifluoroacetic Acid SCHEMBL4491696 | 0.87 | TRPA1 (0.54) | TRPA1KDREGFRLCKFGFR1 | |
| SCHEMBL14771225 | 0.86 | TRPA1 (0.62) | TRPA1KDREGFRLCKRET | |
| SCHEMBL27482627 | 0.84 | TRPA1 (0.51) | TRPA1KDREGFRLCKFGFR1 | |
| SCHEMBL7214411 | 0.82 | KDR (0.67) | TRPA1KDREGFRLCKFGFR1 | |
| SCHEMBL2754217 | 0.82 | TRPA1 (0.64) | TRPA1KDREGFRBRAFRAF1 | |
| SCHEMBL14771448 | 0.81 | TRPA1 (0.62) | TRPA1KDREGFRLCKBRAF | |
| SCHEMBL30000384 | 0.81 | TRPA1 (0.62) | TRPA1KDREGFRLCKBRAF | |
| SCHEMBL4375838 | 0.81 | TRPA1 (0.62) | TRPA1KDREGFRLCKFLT1 | |
| SCHEMBL4491699 | 0.81 | TRPA1 (0.59) | TRPA1KDREGFRLCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |