Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691246 | 1.00 | KDM4E (0.57) | KDM4ECYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL4688334 | 0.91 | LMNA (0.52) | KDM4EKMT2ALMNAPKMALDH1A1 | |
| SCHEMBL4688338 | 0.91 | LMNA (0.52) | KDM4EKMT2ALMNAPKMALDH1A1 | |
| SCHEMBL4692202 | 0.90 | KDM4E (0.60) | KDM4ECYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL4692207 | 0.90 | KDM4E (0.60) | KDM4ECYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL4688679 | 0.82 | LMNA (0.54) | KDM4EKMT2ALMNAPKMGAA | |
| SCHEMBL4688681 | 0.82 | LMNA (0.54) | KDM4EKMT2ALMNAPKMGAA | |
| SCHEMBL4687303 | 0.81 | SMN1; SMN2 (0.57) | KDM4EKMT2ALMNAPKMGAA | |
| SCHEMBL4687309 | 0.81 | SMN1; SMN2 (0.57) | KDM4EKMT2ALMNAPKMGAA | |
| SCHEMBL4692062 | 0.77 | KDM4E (0.57) | KDM4ECYP1A2KMT2ALMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |