Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691310 | 1.00 | POLB (0.57) | POLBCYP2C19NPSR1CYP1A2ALDH1A1 | |
| SCHEMBL4694075 | 0.87 | MAPT (0.59) | CYP2C19NPSR1ALDH1A1MAPTKDM4E | |
| SCHEMBL4692210 | 0.87 | MAPT (0.59) | CYP2C19NPSR1ALDH1A1MAPTKDM4E | |
| SCHEMBL4688859 | 0.86 | KDM4E (0.53) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL4690247 | 0.86 | KMT2A (0.54) | POLBCYP2C19NPSR1CYP1A2ALDH1A1 | |
| SCHEMBL4692795 | 0.84 | MAPT (0.49) | CYP2C19NPSR1ALDH1A1MAPTKDM4E | |
| SCHEMBL4693414 | 0.79 | NPSR1 (0.49) | POLBCYP2C19NPSR1ALDH1A1MAPT | |
| SCHEMBL4693419 | 0.79 | NPSR1 (0.49) | POLBCYP2C19NPSR1ALDH1A1MAPT | |
| SCHEMBL4695113 | 0.79 | CYP1A2 (0.56) | POLBCYP2C19NPSR1CYP1A2ALDH1A1 | |
| SCHEMBL4691315 | 0.79 | POLB (0.53) | POLBCYP2C19NPSR1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |