Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692210 | 1.00 | MAPT (0.59) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4688859 | 0.92 | KDM4E (0.53) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4692795 | 0.92 | MAPT (0.49) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4690247 | 0.89 | KMT2A (0.54) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4691312 | 0.87 | POLB (0.57) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4691310 | 0.87 | POLB (0.57) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4692052 | 0.81 | NPSR1 (0.48) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4692039 | 0.81 | NPSR1 (0.48) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4692051 | 0.81 | NPSR1 (0.48) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4692034 | 0.81 | NPSR1 (0.48) | MAPTKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |