Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 15/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696402 | 0.99 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694203 | 0.92 | CCR5 (0.38) | CCR5KCNH2 | |
| SCHEMBL3282962 | 0.92 | CCR5 (0.36) | CCR5KCNH2 | |
| SCHEMBL4693970 | 0.90 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4691723 | 0.90 | KCNH2 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694419 | 0.89 | CCR5 (0.36) | CCR5KCNH2 | |
| SCHEMBL4690669 | 0.88 | CCR5 (0.45) | CCR5KCNH2 | |
| SCHEMBL4693740 | 0.88 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694952 | 0.87 | CCR5 (0.37) | CCR5KCNH2HTT | |
| SCHEMBL4690611 | 0.87 | CCR5 (0.37) | CCR5KCNH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |