SCHEMBL4691585

SCHEMBL4691585

CC(c1ccc(Cl)cc1)C(CN)c1cncnc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.51
ADRB2 P07550 1/20 0.40
LMNA P02545 3/20 0.37
CYP1A2 P05177 2/20 0.37
THRB P10828 2/20 0.37
MAPT P10636 1/20 0.37
PMP22 Q01453 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
AKT2 P31751 3/20 0.36
GABBR2 O75899 3/20 0.35
GABBR1 Q9UBS5 3/20 0.35
CYP2C9 P11712 2/20 0.35
CYP3A4 P08684 1/20 0.35
ADORA3 P0DMS8 1/20 0.35
NFKB1 P19838 1/20 0.35
DRD3 P35462 1/20 0.35
BLM P54132 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4691852 0.83 ADRB2 (0.37) CYP19A1ADRB2LMNACYP1A2THRB
SCHEMBL5317668 0.83 CYP19A1 (0.55) CYP19A1CYP3A4CYP2C19SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL4691711 0.83 ADRB2 (0.48) ADRB2LMNACYP1A2THRBMAPT
Hydrochloric Acid SCHEMBL5479398 0.81 ADRB2 (0.35) CYP19A1ADRB2LMNACYP1A2THRB
Hydrochloric Acid SCHEMBL5483877 0.81 ADRB2 (0.35) CYP19A1ADRB2LMNACYP1A2THRB
Hydrochloric Acid SCHEMBL5203095 0.80 S1PR1 (0.40) CYP19A1ADRB2LMNACYP1A2THRB
SCHEMBL27668082 0.78 TAAR1 (0.58) ADRB2LMNACYP1A2THRBMAPT
Hydrochloric Acid SCHEMBL5200363 0.77 TAAR1 (0.56) ADRB2LMNACYP1A2THRBGABBR2
Hydrochloric Acid SCHEMBL4688727 0.77 CNR1 (0.35) CYP19A1
Hydrochloric Acid SCHEMBL5263972 0.75 DPP4 (0.34) CYP19A1GABBR2GABBR1CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1496838-A4 SUBSTITUTED AMIDES MERCK & CO INC (US) 2008-07-02 EP disclosed
EP-1663113-A4 SUBSTITUTED SULFONAMIDES MERCK & CO INC (US) 2007-06-13 EP disclosed
EP-1490043-A4 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO INC (US) 2007-05-30 EP disclosed
EP-1494997-A4 SUBSTITUTED ARYL AMIDES MERCK & CO INC (US) 2007-04-11 EP disclosed
EP-1499306-A4 BICYCLIC AMIDES MERCK & CO INC (US) 2007-03-28 EP disclosed
EP-1682494-A4 ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO INC (US) 2006-11-08 EP disclosed
EP-1682494-A1 ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS Merck & Co., Inc. (US) 2006-07-26 EP disclosed
EP-1663113-A2 SUBSTITUTED SULFONAMIDES Merck & Co., Inc. (US) 2006-06-07 EP disclosed
WO-2005044785-A1 ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2005-05-19 WO disclosed
WO-2005027837-A2 SUBSTITUTED SULFONAMIDES MERCK & CO., INC. (US) 2005-03-31 WO disclosed
EP-1499306-A2 BICYCLIC AMIDES Merck & Co., Inc. (US) 2005-01-26 EP disclosed
EP-1496838-A2 SUBSTITUTED AMIDES Merck & Co., Inc. (US) 2005-01-19 EP disclosed
EP-1494997-A1 SUBSTITUTED ARYL AMIDES Merck & Co., Inc. (US) 2005-01-12 EP disclosed
EP-1490043-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS Merck & Co., Inc. (US) 2004-12-29 EP disclosed
WO-2003086288-A2 BICYCLIC AMIDES MERCK & CO., INC. (US) 2003-10-23 WO disclosed
WO-2003087037-A1 SUBSTITUTED ARYL AMIDES MERCK & CO., INC. (US) 2003-10-23 WO disclosed
WO-2003082190-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-10-09 WO disclosed
WO-2003077847-A2 SUBSTITUTED AMIDES MERCK & CO., INC. (US) 2003-09-25 WO disclosed