Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691686 | 0.93 | MAPT (0.48) | TP53MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4690978 | 0.92 | MAPT (0.40) | TP53MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4694966 | 0.91 | NR1H4 (0.42) | TP53MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4691661 | 0.87 | MAPT (0.45) | TP53MAPTSMN1; SMN2POLBP2RY12 | |
| SCHEMBL4692067 | 0.86 | MAPT (0.41) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL4691333 | 0.86 | MAPT (0.45) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL4691706 | 0.85 | MAPT (0.47) | TP53MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4694232 | 0.85 | PDK1 (0.42) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL4691889 | 0.84 | MAPT (0.43) | TP53MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4690373 | 0.84 | TSHR (0.41) | TP53MAPTSMN1; SMN2ALDH1A1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |