Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 15/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 3/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696460 | 0.86 | CCR5 (0.51) | CCR5MLNRABCB11LMNACTSD | |
| SCHEMBL4692831 | 0.84 | CCR5 (0.50) | CCR5MLNRABCB11LMNACTSD | |
| SCHEMBL4695445 | 0.81 | CCR5 (0.55) | CCR5MLNRABCB11LMNACTSD | |
| SCHEMBL4695085 | 0.80 | CCR5 (0.61) | CCR5 | |
| SCHEMBL4693606 | 0.80 | CCR5 (0.46) | CCR5MLNRABCB11LMNACTSD | |
| SCHEMBL4695578 | 0.79 | CCR5 (0.66) | CCR5 | |
| SCHEMBL4695622 | 0.79 | CCR5 (0.66) | CCR5 | |
| SCHEMBL4691513 | 0.79 | CCR5 (0.55) | CCR5MLNRABCB11LMNACTSD | |
| SCHEMBL4692262 | 0.79 | CCR5 (0.68) | CCR5 | |
| SCHEMBL4694657 | 0.79 | CCR5 (0.68) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |