Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691718 | 0.89 | KCNA5 (0.64) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL4685933 | 0.86 | KCNA5 (0.67) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL4685230 | 0.86 | KCNA5 (0.59) | KCNA5KCNH2MAPK8ACHEMAPT | |
| SCHEMBL4688398 | 0.79 | KCNA5 (0.64) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL1381998 | 0.79 | KCNA5 (0.76) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL2903883 | 0.77 | KCNA5 (0.66) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL1382996 | 0.77 | KCNA5 (0.76) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL3115349 | 0.77 | KCNA5 (0.76) | KCNA5KCNH2MAPK8DPP4ALDH1A1 | |
| SCHEMBL4685992 | 0.77 | KCNA5 (0.76) | KCNA5KCNH2MAPK8DPP4 | |
| SCHEMBL2904903 | 0.77 | KCNA5 (0.76) | KCNA5KCNH2MAPK8DPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322619-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-01-23 | — | — | EP | disclosed |
| US-6870055-B2 | Isoquinolinone potassium channels inhibitors | MERCK & CO., INC. (US) | 2005-03-22 | — | — | US | disclosed |