Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692232 | 0.93 | HPGD (0.44) | HPGDMAPK1HTTHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL4694652 | 0.87 | METTL3 (0.43) | HPGDGRM1LMNAALDH1A1METTL3 | |
| Hydrochloric Acid SCHEMBL5545888 | 0.86 | METTL3 (0.42) | HPGDGRM1LMNAALDH1A1METTL3 | |
| Hydrochloric Acid SCHEMBL4694551 | 0.84 | GRM1 (0.45) | HPGDGRM1ALDH1A1METTL3RAB9A | |
| Hydrochloric Acid SCHEMBL4692138 | 0.84 | GRM1 (0.45) | HPGDGRM1ALDH1A1METTL3RAB9A | |
| Hydrochloric Acid SCHEMBL4694679 | 0.83 | METTL3 (0.42) | HPGDHTTHSD17B10GRM1LMNA | |
| Hydrochloric Acid SCHEMBL4691990 | 0.83 | GRM1 (0.45) | HPGDGRM1LMNAALDH1A1METTL3 | |
| Hydrochloric Acid SCHEMBL4694677 | 0.83 | METTL3 (0.42) | HPGDHTTHSD17B10GRM1LMNA | |
| Hydrochloric Acid SCHEMBL4689363 | 0.81 | GRM1 (0.45) | HPGDGRM1ALDH1A1METTL3MAPT | |
| Hydrochloric Acid SCHEMBL4691954 | 0.81 | GRM1 (0.52) | HPGDHTTGRM1ALDH1A1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1486501-B1 | AMINOMETHYL-SUBSTITUTED THIAZOLOBENZIMIDAZOLE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2008-09-10 | — | — | EP | disclosed |
| US-7250429-B2 | Aminomethyl-substituted thiazolobenzimidazole compounds | ASTELLAS PHARMA INC. (JP) | 2007-07-31 | — | — | US | disclosed |
| US-20050148642-A1 | Aminomethyl-substituted thiazolobenzimidazole derivative | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | US | disclosed |
| EP-1486501-A1 | AMINOMETHYL-SUBSTITUTED THIAZOLOBENZIMIDAZOLE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2004-12-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148642-A1 | Aminomethyl-substituted thiazolobenzimidazole derivative | GRM1, GRIN1, GRM3 | HPGD 3719/4885MAPK1 734/4885HTT 3959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.