Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 20/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.71 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743151 | 0.89 | LTA4H (0.76) | LTA4HKCNH2EPHX2 | |
| SCHEMBL4694062 | 0.89 | LTA4H (0.79) | LTA4HKCNH2 | |
| SCHEMBL4689162 | 0.88 | LTA4H (0.67) | LTA4HKCNH2EPHX2 | |
| SCHEMBL4689059 | 0.87 | LTA4H (0.66) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2168411 | 0.87 | LTA4H (0.79) | LTA4HKCNH2 | |
| SCHEMBL4693677 | 0.87 | LTA4H (0.63) | LTA4HKCNH2EPHX2 | |
| SCHEMBL4695441 | 0.86 | LTA4H (0.71) | LTA4HKCNH2 | |
| SCHEMBL2168100 | 0.84 | LTA4H (0.82) | LTA4HKCNH2 | |
| SCHEMBL2169583 | 0.84 | LTA4H (0.84) | LTA4HKCNH2 | |
| SCHEMBL2169267 | 0.83 | LTA4H (1.00) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | claimed |