Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169992 | 0.87 | LTA4H (0.57) | LTA4HKCNH2TACR2TACR1HRH1 | |
| SCHEMBL2168040 | 0.83 | LTA4H (0.77) | LTA4HKCNH2 | |
| SCHEMBL2169586 | 0.80 | LTA4H (0.74) | LTA4HKCNH2 | |
| SCHEMBL4743151 | 0.80 | LTA4H (0.76) | LTA4HKCNH2 | |
| SCHEMBL2167824 | 0.79 | LTA4H (0.75) | LTA4HKCNH2 | |
| SCHEMBL2169369 | 0.79 | LTA4H (0.75) | LTA4HKCNH2 | |
| SCHEMBL2168556 | 0.78 | LTA4H (0.74) | LTA4HKCNH2 | |
| SCHEMBL2167878 | 0.74 | LTA4H (0.79) | LTA4HKCNH2LMNASMN1; SMN2 | |
| SCHEMBL2169707 | 0.74 | LTA4H (0.58) | LTA4HKCNH2 | |
| SCHEMBL2168408 | 0.73 | LTA4H (0.78) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | claimed |