Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777729 | 0.96 | HRH3 (0.59) | HRH3SMN1; SMN2HPGDPANK3MEN1 | |
| SCHEMBL4650459 | 0.96 | HRH3 (0.59) | HRH3SMN1; SMN2HPGDPANK3MEN1 | |
| SCHEMBL1779272 | 0.83 | CCR2 (0.51) | HRH3SMN1; SMN2MEN1KMT2ADPP4 | |
| SCHEMBL28780251 | 0.82 | CCR2 (0.50) | HRH3PANK3 | |
| SCHEMBL27741688 | 0.82 | CCR2 (0.55) | HRH3PANK3DPP4 | |
| SCHEMBL1777895 | 0.82 | CCR2 (0.50) | HRH3PANK3 | |
| SCHEMBL1777401 | 0.82 | CCR2 (0.55) | HRH3PANK3DPP4 | |
| SCHEMBL1944917 | 0.80 | CCR2 (0.58) | HRH3PANK3 | |
| SCHEMBL1778248 | 0.79 | KDM4E (0.54) | HRH3SMN1; SMN2HPGDPANK3MEN1 | |
| SCHEMBL1777190 | 0.79 | CCR2 (0.47) | HRH3SMN1; SMN2HPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966187-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071952-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |