Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
| ▸ | KIF5B | P33176 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751092 | 0.79 | ADORA3 (0.56) | EGFRGLAHTTABCG2GAA | |
| SCHEMBL1707023 | 0.73 | HTT (0.56) | EGFRGLAHTTABCG2GAA | |
| SCHEMBL28748550 | 0.72 | EGFR (0.72) | EGFRGLAHTTABCG2GAA | |
| SCHEMBL4431055 | 0.71 | MAP4K4 (0.54) | EGFRESR1ESR2 | |
| SCHEMBL5453911 | 0.70 | EGFR (0.46) | EGFRGLAHTTABCG2RET | |
| SCHEMBL20813449 | 0.67 | EGFR (0.44) | EGFRGLAHTTABCG2RET | |
| SCHEMBL5465224 | 0.67 | PDE4A (0.53) | EGFRHTTGAARETKDR | |
| SCHEMBL8871490 | 0.67 | EGFR (0.72) | EGFRGLAHTTRETKDR | |
| SCHEMBL1439251 | 0.66 | EGFR (0.61) | EGFRBRAFADORA3 | |
| SCHEMBL22164672 | 0.65 | EGFR (0.49) | EGFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |