Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | KIF5B | P33176 | 1/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 18/20 | 0.60 |
| ▸ | KDR | P35968 | 8/20 | 0.60 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693034 | 0.97 | RET (0.59) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4689353 | 0.88 | KDR (0.55) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4690909 | 0.86 | EGFR (0.46) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4690872 | 0.84 | EGFR (0.58) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4693982 | 0.83 | EPHB4 (0.45) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4693103 | 0.83 | EGFR (0.58) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4688686 | 0.83 | EPHA2 (0.67) | EPHA2KDREPHB4ERBB2 | |
| SCHEMBL4427825 | 0.83 | EGFR (0.62) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4692027 | 0.83 | ALDH1A1 (0.46) | RETKIF5BEPHA2KDREPHB4 | |
| SCHEMBL4687812 | 0.82 | EGFR (0.46) | RETKIF5BEPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |