Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693931 | 0.82 | TAAR1 (0.43) | TAAR1SLC6A2SLC6A3MAOASLC6A4 | |
| SCHEMBL1718685 | 0.81 | TAAR1 (0.64) | TAAR1SLC6A2SLC6A3MAOASLC6A4 | |
| SCHEMBL158968 | 0.81 | TAAR1 (0.64) | TAAR1SLC6A2SLC6A3MAOASLC6A4 | |
| SCHEMBL1718675 | 0.81 | TAAR1 (0.64) | TAAR1SLC6A2SLC6A3MAOASLC6A4 | |
| SCHEMBL13416785 | 0.80 | TRPA1 (0.62) | TAAR1SLC6A2SLC6A3LOXL2MAOA | |
| SCHEMBL19342840 | 0.80 | TAAR1 (0.69) | TAAR1SLC6A2 | |
| SCHEMBL4388223 | 0.80 | TAAR1 (0.69) | TAAR1SLC6A2 | |
| SCHEMBL13416380 | 0.80 | SLC6A2 (0.69) | TAAR1SLC6A2SLC6A3MAOASLC6A4 | |
| SCHEMBL4692957 | 0.80 | SLC6A2 (0.69) | TAAR1SLC6A2SLC6A3MAOASLC6A4 | |
| SCHEMBL7286460 | 0.79 | TAAR1 (0.67) | TAAR1SLC6A2SLC6A3MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1375489-B1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |
| US-6916806-B2 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2005-07-12 | — | — | US | disclosed |
| US-20040116326-A1 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1375489-A1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |