Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486014 | 0.85 | POLB (0.57) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4493695 | 0.81 | HDAC1 (0.54) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3324240 | 0.78 | HTR6 (0.60) | ADRB1HTR6HTR3EHTR3BHTR1A | |
| SCHEMBL4468502 | 0.73 | POLB (0.60) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4492877 | 0.73 | POLB (0.53) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4483596 | 0.73 | POLB (0.53) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4558610 | 0.73 | POLB (0.50) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4464670 | 0.72 | POLB (0.51) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4480619 | 0.70 | POLB (0.49) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL31430299 | 0.70 | CHRM5 (0.58) | GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603880-B1 | QUINOLINONE/BENZOXAZINONE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | EP | claimed |