Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.54 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047072 | 1.00 | ANPEP (0.54) | ANPEPERAP2KDM4ETAAR1CTSD | |
| SCHEMBL4695118 | 1.00 | ANPEP (0.54) | ANPEPERAP2KDM4ETAAR1CTSD | |
| SCHEMBL5720870 | 1.00 | ANPEP (0.54) | ANPEPERAP2KDM4ETAAR1CTSD | |
| Hydrochloric Acid SCHEMBL5930110 | 0.99 | ANPEP (0.53) | ANPEPERAP2KDM4ETAAR1CTSD | |
| SCHEMBL5930121 | 0.99 | ANPEP (0.52) | ANPEPERAP2KDM4ETAAR1CTSD | |
| Hydrochloric Acid SCHEMBL5220187 | 0.97 | ANPEP (0.52) | ANPEPERAP2KDM4ETAAR1CTSD | |
| SCHEMBL4692517 | 0.96 | ANPEP (0.49) | ANPEPERAP2KDM4ETAAR1CTSD | |
| Hydrochloric Acid SCHEMBL5216767 | 0.94 | ANPEP (0.48) | ANPEPERAP2KDM4ETAAR1CTSD | |
| SCHEMBL5805296 | 0.93 | GRIN2B (0.48) | ANPEPERAP2KDM4ECTSDBACE1 | |
| SCHEMBL14253003 | 0.93 | GRIN2B (0.48) | ANPEPERAP2KDM4ECTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |