Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692982 | 0.80 | LTA4H (0.64) | LTA4HKCNH2EPHX2 | |
| SCHEMBL5610044 | 0.79 | LTA4H (0.60) | LTA4HKCNH2EPHX2PPARGPPARA | |
| Hydrochloric Acid SCHEMBL2170240 | 0.79 | LTA4H (0.62) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2179829 | 0.78 | LTA4H (0.64) | LTA4HKCNH2EPHX2 | |
| SCHEMBL5001616 | 0.78 | LTA4H (0.44) | LTA4HKCNH2PPARGPPARA | |
| SCHEMBL4998290 | 0.78 | LTA4H (0.44) | LTA4HKCNH2 | |
| SCHEMBL22209100 | 0.78 | LTA4H (0.56) | LTA4HKCNH2EPHX2PPARGPPARA | |
| SCHEMBL22209144 | 0.76 | LTA4H (0.57) | LTA4HKCNH2EPHX2PPARGPPARA | |
| Ammonia Solution, Strong SCHEMBL6365045 | 0.76 | LTA4H (0.53) | LTA4HKCNH2 | |
| SCHEMBL22224215 | 0.75 | LTA4H (0.56) | LTA4HKCNH2EPHX2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | claimed |