Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693179 | 0.97 | MAPK1 (0.33) | MAPK1DRD2DRD4HRH4KCNK2 | |
| SCHEMBL4693873 | 0.91 | NPC1 (0.32) | NPC1 | |
| SCHEMBL4695749 | 0.90 | MAPK1 (0.32) | MAPK1CHRM2HTR1AADRA2ADRD1 | |
| SCHEMBL4694428 | 0.88 | MAPK1 (0.33) | MAPK1DRD2DRD4HRH4KCNK2 | |
| SCHEMBL4692968 | 0.86 | MAPK1 (0.32) | MAPK1CHRM2HTR1AADRA2ADRD1 | |
| SCHEMBL4696667 | 0.86 | MAPK1 (0.36) | MAPK1DRD2DRD4HRH4KCNK2 | |
| SCHEMBL4696318 | 0.82 | MAPK1 (0.36) | MAPK1DRD2DRD4HRH4KCNK2 | |
| SCHEMBL4692174 | 0.80 | CACNA1H (0.32) | DRD2DRD3 | |
| SCHEMBL4696998 | 0.79 | MAPK1 (0.35) | MAPK1DRD2DRD4HRH4KCNK2 | |
| SCHEMBL5436718 | 0.79 | F11 (0.38) | MAPK1DRD2DRD4HRH4KCNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509528-B1 | 1,3-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2008-09-24 | — | — | EP | claimed |