Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | JAK3 | P52333 | 8/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | SIK1 | P57059 | 1/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.36 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694125 | 0.84 | NTRK1 (0.48) | JAK2JAK3NTRK1FLT3FGFR1 | |
| SCHEMBL4694696 | 0.82 | NTRK1 (0.50) | JAK2JAK3NTRK1IGF1R | |
| SCHEMBL4696082 | 0.80 | NTRK1 (0.49) | JAK2JAK3NTRK1AURKAGRK6 | |
| SCHEMBL29794832 | 0.74 | JAK2 (0.58) | JAK2JAK3NTRK1FLT3FGFR1 | |
| SCHEMBL57147 | 0.74 | NTRK1 (0.56) | JAK2JAK3NTRK1FLT3FGFR1 | |
| SCHEMBL4696885 | 0.72 | NTRK1 (0.43) | JAK2JAK3NTRK1AURKACDK2 | |
| SCHEMBL4696871 | 0.72 | NTRK1 (0.43) | JAK2JAK3NTRK1AURKACDK2 | |
| SCHEMBL16489588 | 0.72 | TLR7 (0.43) | TLR7EGFRADORA2BGRM5 | |
| SCHEMBL16489587 | 0.72 | TLR7 (0.43) | TLR7EGFRADORA2BGRM5 | |
| SCHEMBL10027491 | 0.70 | JAK3 (0.58) | JAK2JAK3NTRK1FLT3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |