Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475665 | 0.89 | HPGD (0.51) | HPGDMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL475759 | 0.81 | HPGD (0.70) | HPGDMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL475423 | 0.78 | HPGD (0.62) | HPGDLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL3646615 | 0.77 | BACE1 (0.55) | — | |
| SCHEMBL4206838 | 0.74 | HPGD (0.50) | HPGDLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4187307 | 0.73 | POLB (0.72) | HPGDLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL14427603 | 0.72 | MEN1 (0.66) | HPGDMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3507911 | 0.71 | HPGD (0.59) | HPGDLMNAALDH1A1KDM4EHTT | |
| SCHEMBL1006444 | 0.70 | HTT (0.71) | HPGDMEN1KMT2AALDH1A1HTT | |
| SCHEMBL8249331 | 0.70 | KDM4E (0.70) | HPGDMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871739-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006110668-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-10-19 | — | — | WO | disclosed |