Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Butyrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 8/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.92 |
| ▸ | AR | P10275 | 3/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.68 |
| ▸ | SHBG | P04278 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Butyrate SCHEMBL14339600 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL21111521 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL14473210 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL111478 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL11209085 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL14936050 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL8397588 | 0.98 | NR3C2 (0.97) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Valerate SCHEMBL11356233 | 0.98 | HIF1A (0.97) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Valerate SCHEMBL80603 | 0.96 | HIF1A (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Valerate SCHEMBL21111527 | 0.96 | HIF1A (1.00) | NR3C2PGRNR3C1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15235 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4744657-A1 | THERAPEUTIC AGENT FOR HUMAN GRAFT VERSUS HOST DISEASE AND COMBINATION THEREOF | National University Corporation Okayama University (JP) | 2026-05-20 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260103492-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2026-04-16 | — | — | US | claimed |
| EP-4301343-B1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC BIOPHARMACEUTICALS INC (US) | 2025-11-19 | — | — | EP | claimed |
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| US-20250319104-A1 | MOISTURIZING CREAM FOR RADIATION DERMATITIS | PERRY ARTHUR W (US) | 2025-10-16 | — | — | US | claimed |
| US-12421281-B2 | Cyclosporine compositions and methods of use | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-09-23 | — | — | US | claimed |
| US-20250288585-A1 | SYNERGISTIC COMPOSITIONS FOR ENHANCED HAIR GROWTH AND METHODS FOR TREATING HAIR LOSS | THE JOHNS HOPKINS UNIVERSITY | 2025-09-18 | — | — | US | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| EP-0069385-A2 | Use of eucalyptol for enhancing skin permeation of bioaffecting agents | MERCK & CO. INC. (US) | 1983-01-12 | — | — | EP | claimed |
| EP-0069423-A1 | Composition for topical application to the body | YAMANOUCHI EUROPE B.V. (NL) | 1983-01-12 | — | — | EP | claimed |
| EP-0068553-A1 | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1983-01-05 | — | — | EP | claimed |
| US-4367224-A | ANTIINFLAMMATORY AGENTS, SKIN DISORDERS | SCOTT EUGENE J VAN | 1983-01-04 | — | — | US | claimed |
| US-4343798-A | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-08-10 | — | — | US | claimed |
| US-4333927-A | CORTICOSTEROID, PHOSPHATIDE, BUTYLHYDROXYANISOLE AND/OR BUTYLHYDROXYTOLUENE | MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) | 1982-06-08 | — | — | US | claimed |
| EP-0036138-A2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |
| US-4246261-A | HYDROXY ACIDS, ESTERS, LACTONES | SCOTT EUGENE J VAN | 1981-01-20 | — | — | US | claimed |
| US-4221787-A | Esteramide prodrugs of anti-inflammatory corticosteroids | INTERX RESEARCH CORPORATION (US) | 1980-09-09 | — | — | US | claimed |
| US-4137311-A | CORTICOSTEROIDS, METAL ADDUCTS OF BIS(2-PYRIDYL-1-OXIDE)-DISULFIDE; DERMATITIS, ANTIINFLAMMATORY | WILLIAM H. RORER, INC. (US) | 1979-01-30 | — | — | US | claimed |