Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Butyrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 8/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.92 |
| ▸ | AR | P10275 | 3/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.68 |
| ▸ | SHBG | P04278 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Butyrate SCHEMBL4695 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL14339600 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL14473210 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL111478 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL11209085 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL14936050 | 1.00 | NR3C2 (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Butyrate SCHEMBL8397588 | 0.98 | NR3C2 (0.97) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Valerate SCHEMBL11356233 | 0.98 | HIF1A (0.97) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Valerate SCHEMBL80603 | 0.96 | HIF1A (1.00) | NR3C2PGRNR3C1HIF1AKMT2A | |
| Hydrocortisone Valerate SCHEMBL21111527 | 0.96 | HIF1A (1.00) | NR3C2PGRNR3C1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230079407-A1 | ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. | 2023-03-16 | — | — | US | disclosed |
| US-11377502-B2 | Anti-MSR1 antibodies and methods of use thereof | REGENERON PHARMACEUTICALS, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20190209702-A1 | STEROIDS AND ANTIBODY-CONJUGATES THEREOF | REGENERON PHARMACEUTICALS, INC. | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190209702-A1 | STEROIDS AND ANTIBODY-CONJUGATES THEREOF | SERPINA6, NR3C1, NR3C2 | NR3C1 2/4885NR3C2 3/4885PGR 223/4885 |
| US-20230079407-A1 | ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF | CD47, MSR1, LDLR | NR3C1 1628/4885NR3C2 2052/4885PGR 3140/4885 |
| US-11377502-B2 | Anti-MSR1 antibodies and methods of use thereof | CD47, MSR1, LDLR | NR3C1 1628/4885NR3C2 2052/4885PGR 3140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.