Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.58 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | GRK6 | P43250 | 6/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696082 | 0.85 | NTRK1 (0.49) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4748708 | 0.84 | NTRK1 (0.54) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4696177 | 0.83 | NTRK1 (0.59) | NTRK1JAK2JAK3GRK6AURKA | |
| SCHEMBL3137771 | 0.83 | NTRK1 (0.54) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4696037 | 0.82 | NTRK1 (0.85) | NTRK1JAK2JAK3 | |
| SCHEMBL23808896 | 0.81 | NTRK1 (0.75) | NTRK1JAK2JAK3GRK6AURKA | |
| SCHEMBL2565727 | 0.80 | JAK2 (0.53) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL2565732 | 0.80 | JAK2 (0.53) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL2486709 | 0.79 | JAK3 (0.75) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL2486710 | 0.79 | JAK3 (0.75) | NTRK1JAK2JAK3LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |