Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10138054 | 0.81 | KDM1A (0.69) | KDM1AALDH1A1CYP1A2CYP3A4SMN1; SMN2 | |
| SCHEMBL8481692 | 0.80 | TSHR (0.59) | ALDH1A1CYP1A2CYP3A4TSHRHPGD | |
| SCHEMBL469530 | 0.79 | KMT2A (0.73) | KDM1AALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL17509892 | 0.78 | TSHR (0.62) | ALDH1A1CYP1A2TSHRHPGDSMN1; SMN2 | |
| SCHEMBL6679711 | 0.78 | TSHR (0.61) | ALDH1A1CYP1A2CYP3A4TSHRHPGD | |
| SCHEMBL4795850 | 0.77 | ALDH1A1 (0.61) | ALDH1A1TSHRHPGDSMN1; SMN2RAB9A | |
| SCHEMBL469608 | 0.76 | KDM1A (0.55) | KDM1AALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL242212 | 0.76 | TSHR (0.59) | ALDH1A1CYP1A2CYP3A4TSHRHPGD | |
| SCHEMBL29678256 | 0.76 | TSHR (0.59) | ALDH1A1CYP1A2CYP3A4TSHRHPGD | |
| SCHEMBL10472154 | 0.76 | TSHR (0.73) | ALDH1A1CYP1A2CYP3A4TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527805-B2 | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-27 | — | — | US | disclosed |
| US-20140011857-A1 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-01-09 | — | — | US | disclosed |
| WO-2012034116-A2 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140011857-A1 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | KDM1B, DOT1L, EHMT1 | KDM1A 6/4885ALDH1A1 1115/4885CYP1A2 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.