Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.64 |
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 8/20 | 0.52 |
| ▸ | IKBKB | O14920 | 3/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692325 | 0.91 | FYN (0.58) | MKNK1PIM1FYNIKBKB | |
| SCHEMBL3648939 | 0.90 | PIM1 (0.62) | MKNK1PIM1FYNHSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL3452909 | 0.89 | PIM1 (0.61) | MKNK1PIM1FYNHSD17B10MAPK1 | |
| SCHEMBL3642279 | 0.88 | PIM1 (0.64) | PIM1FYN | |
| SCHEMBL13110863 | 0.85 | PIM1 (0.49) | MKNK1PIM1FYNMAPTKDM4E | |
| SCHEMBL4694760 | 0.85 | FYN (0.64) | MKNK1PIM1FYN | |
| SCHEMBL1054955 | 0.84 | PIM1 (0.62) | MKNK1PIM1FYN | |
| SCHEMBL13234779 | 0.84 | FYN (0.65) | MKNK1PIM1FYNIKBKBCHUK | |
| Hydrochloric Acid SCHEMBL3453189 | 0.84 | PIM1 (0.48) | MKNK1PIM1FYNMAPTKDM4E | |
| SCHEMBL4695530 | 0.84 | FYN (0.74) | PIM1FYNMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |