Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 17/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054937 | 0.85 | FYN (1.00) | FYN | |
| SCHEMBL4692325 | 0.84 | FYN (0.58) | FYNPIM1 | |
| SCHEMBL1054955 | 0.84 | PIM1 (0.62) | FYNPIM1 | |
| SCHEMBL4695518 | 0.84 | MKNK1 (0.64) | FYNPIM1KDM4EALDH1A1MAPT | |
| SCHEMBL3648939 | 0.83 | PIM1 (0.62) | FYNPIM1HSD17B10 | |
| SCHEMBL4695075 | 0.83 | PIM1 (0.65) | FYNPIM1 | |
| Hydrochloric Acid SCHEMBL3452909 | 0.82 | PIM1 (0.61) | FYNPIM1HSD17B10 | |
| SCHEMBL13234627 | 0.82 | FYN (1.00) | FYNPIM1 | |
| SCHEMBL30521869 | 0.82 | FYN (1.00) | FYNPIM1 | |
| SCHEMBL3642279 | 0.82 | PIM1 (0.64) | FYNPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |