Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | BRD4 | O60885 | 10/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4210229 | 1.00 | KMT2A (0.44) | KMT2ABRD4CYP19A1MEN1MAPT | |
| SCHEMBL4210226 | 1.00 | KMT2A (0.44) | KMT2ABRD4CYP19A1MEN1MAPT | |
| SCHEMBL3201062 | 0.86 | KDM4E (0.45) | KMT2ABRD4CYP19A1LMNASMN1; SMN2 | |
| SCHEMBL4216922 | 0.83 | ALDH1A1 (0.51) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4216929 | 0.83 | ALDH1A1 (0.51) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL28253627 | 0.82 | KMT2A (0.54) | KMT2ABRD4MEN1MAPTTDP1 | |
| SCHEMBL3807614 | 0.78 | BRD4 (0.58) | KMT2ABRD4MAPTLMNASMN1; SMN2 | |
| SCHEMBL3807611 | 0.78 | BRD4 (0.58) | KMT2ABRD4MAPTLMNASMN1; SMN2 | |
| SCHEMBL6214263 | 0.78 | BRD4 (0.58) | KMT2ABRD4MAPTLMNASMN1; SMN2 | |
| SCHEMBL4351537 | 0.78 | KDM4E (0.42) | KMT2ABRD4CYP19A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-B1 | TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | EP | disclosed |