Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 15/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | ATF1 | P18846 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574203 | 0.81 | KIF11 (0.42) | MAPTNFKB1 | |
| SCHEMBL5189113 | 0.80 | KDR (0.48) | PLAUP2RY14 | |
| SCHEMBL4412667 | 0.77 | BTK (0.47) | — | |
| SCHEMBL17316222 | 0.76 | ABL1 (0.49) | HTT | |
| SCHEMBL4482180 | 0.76 | NR2E1 (0.67) | — | |
| SCHEMBL4418714 | 0.75 | MAPK14 (0.45) | — | |
| SCHEMBL4714607 | 0.75 | MAP3K7 (0.39) | MITFMAPTPOLBHTTKDM4E | |
| SCHEMBL4464990 | 0.73 | MAPT (0.66) | MITFMAPTPOLBHTTKDM4E | |
| SCHEMBL4412373 | 0.73 | RXFP1 (0.45) | — | |
| SCHEMBL4565580 | 0.72 | P2RY14 (0.34) | PLAUATF1NFKB1P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919924-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007022268-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |