Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 7/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419022 | 0.87 | HTR7 (0.65) | KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL2075223 | 0.87 | KCNK3 (0.53) | KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL2075896 | 0.81 | HTR7 (0.77) | KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL10799759 | 0.75 | CREBBP (0.72) | KCNK3 | |
| SCHEMBL17317503 | 0.74 | KCNK3 (0.64) | KCNK3 | |
| SCHEMBL2073889 | 0.74 | HTR7 (0.56) | KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL10805154 | 0.74 | KCNK3 (0.66) | KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL14784434 | 0.73 | KCNK3 (0.80) | KCNK3 | |
| SCHEMBL2075636 | 0.73 | HTR7 (0.60) | KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL2076624 | 0.73 | HTR7 (0.66) | KCNK3HTR7HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944306-A1 | Fused heterocyclic compounds as serotonin receptor modulators | Janssen Pharmaceutica, N.V. (BE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1905774-A1 | Fused heterocyclic compounds as serotonin receptor modulators | Janssen Pharmaceutica, N.V. (BE) | 2008-04-02 | — | — | EP | disclosed |
| EP-1668014-A2 | FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005040169-A2 | FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-06 | — | — | WO | disclosed |