SCHEMBL4696014

SCHEMBL4696014

Cc1nc(CN2CCC(C(CC=O)c3ccc4nc(C)sc4c3)CC2)cs1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 0.41
ACHE P22303 2/20 0.41
KMT2A Q03164 2/20 0.39
GAA P10253 1/20 0.36
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ENPP2 Q13822 1/20 0.34
ALOX15 P16050 1/20 0.33
SCN5A Q14524 1/20 0.33
SCN9A Q15858 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
CHRM4 P08173 2/20 0.33
ACKR3 P25106 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5570200 0.85 ACHE (0.54) BCHEACHEKMT2AALDH1A1SMN1; SMN2
SCHEMBL4288287 0.83 BCHE (0.46) BCHEACHEKMT2AGAAALDH1A1
SCHEMBL9383157 0.78 SLC6A2 (0.39) KMT2AALDH1A1SMN1; SMN2MEN1MAPT
SCHEMBL4288281 0.73 BCHE (0.54) BCHEACHEKMT2AGAAALDH1A1
SCHEMBL221729 0.72 ACHE (0.75) BCHEACHEKMT2AALDH1A1SMN1; SMN2
SCHEMBL4289984 0.68 BCHE (0.61) BCHEACHEKMT2AALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL9385815 0.67 BCHE (0.61) BCHEACHEKMT2AALDH1A1SMN1; SMN2
SCHEMBL4287391 0.65 HRH3 (0.42) BCHEACHEKMT2AALDH1A1SMN1; SMN2
SCHEMBL14534650 0.64 SMN1; SMN2 (0.53) KMT2AGAAALDH1A1SMN1; SMN2KDM4E
SCHEMBL6994266 0.63 KMT2A (0.53) KMT2AGAAALDH1A1SMN1; SMN2SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1909910-A1 BENZIMIDAZOLE DERIVATIVES AS SIRTUIN MODULATORS Sirtris Pharmaceuticals, Inc. (US) 2008-04-16 EP disclosed
EP-1850840-A2 NOVEL COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE AND BLOOD COAGULATION DISORDERS Sirtris Pharmaceuticals, Inc. (US) 2007-11-07 EP disclosed
WO-2007019416-A1 BENZIMIDAZOLE DERIVATIVES AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC. (US) 2007-02-15 WO disclosed
WO-2006094233-A1 N,N'-DICYCLIC ISOTHIOUREA SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC. (US) 2006-09-08 WO disclosed
WO-2006094248-A1 ARYL-SUBSTITUTED CYCLIC SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC. (US) 2006-09-08 WO disclosed
WO-2006076681-A2 NOVEL COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE AND BLOOD COAGULATION DISORDERS SIRTRIS PHARMACEUTICALS, INC. (US) 2006-07-20 WO disclosed