Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696925 | 0.89 | CCR5 (0.40) | CCR5ALDH1A1KCNH2 | |
| SCHEMBL4691464 | 0.88 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694419 | 0.88 | CCR5 (0.36) | CCR5KCNH2 | |
| SCHEMBL4693620 | 0.87 | CCR5 (0.44) | CCR5KCNH2 | |
| SCHEMBL4694952 | 0.86 | CCR5 (0.37) | LMNAUBE2MDCUN1D1CCR5KCNH2 | |
| SCHEMBL4695967 | 0.86 | CCR5 (0.36) | CCR5ALDH1A1KCNH2 | |
| SCHEMBL4690669 | 0.86 | CCR5 (0.45) | CCR5KCNH2 | |
| SCHEMBL4696402 | 0.86 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694980 | 0.86 | CCR5 (0.42) | L3MBTL1LMNAUBE2MDCUN1D1CCR5 | |
| SCHEMBL4694067 | 0.85 | CCR5 (0.34) | CCR5KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |