Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MGMT | P16455 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137390 | 0.86 | HTT (0.46) | CYP1A2CYP3A4CYP2C9CYP2C19NTRK1 | |
| SCHEMBL4696420 | 0.85 | NTRK1 (0.51) | CYP1A2CYP2C9CYP2C19NTRK1MKNK1 | |
| SCHEMBL4073888 | 0.84 | NTRK1 (0.53) | NTRK1MKNK1MKNK2 | |
| SCHEMBL3137650 | 0.82 | HTT (0.48) | CYP1A2CYP3A4CYP2C9CYP2C19NTRK1 | |
| SCHEMBL2571347 | 0.80 | HTT (0.46) | CYP1A2CYP3A4CYP2C9CYP2C19NTRK1 | |
| SCHEMBL3667400 | 0.79 | NTRK1 (0.52) | NTRK1PRKCQ | |
| SCHEMBL3775237 | 0.79 | NTRK1 (0.52) | NTRK1PRKCQ | |
| SCHEMBL2577693 | 0.79 | PRKCQ (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19NTRK1 | |
| SCHEMBL3781156 | 0.78 | JAK2 (0.50) | NTRK1 | |
| SCHEMBL2569963 | 0.72 | NTRK1 (0.48) | CYP1A2CYP3A4CYP2C9CYP2C19NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |