Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | C1R | P00736 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648882 | 0.85 | CXCR2 (0.64) | CXCR2CXCR1CYP2C9MAPTHPGD | |
| SCHEMBL4698274 | 0.79 | CXCR2 (0.74) | CXCR2CXCR1CYP2C9MAPTHPGD | |
| SCHEMBL18953554 | 0.76 | CXCR2 (0.51) | CXCR2CXCR1MAPTHPGDPKM | |
| SCHEMBL18953652 | 0.75 | CXCR2 (0.42) | CXCR2CXCR1MAPTNPC1KMT2A | |
| SCHEMBL18953334 | 0.75 | CXCR2 (0.44) | CXCR2CXCR1MAPTNPC1KMT2A | |
| SCHEMBL18953455 | 0.74 | CXCR2 (0.43) | CXCR2CXCR1MAPTNPC1KMT2A | |
| SCHEMBL18953374 | 0.74 | CXCR2 (0.43) | CXCR2CXCR1MAPTHPGDRAB9A | |
| SCHEMBL4648909 | 0.73 | CXCR2 (0.68) | CXCR2CXCR1CYP2C9MAPTHPGD | |
| SCHEMBL4686262 | 0.72 | CXCR2 (0.75) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D | |
| SCHEMBL18953514 | 0.72 | CXCR2 (0.46) | CXCR2CXCR1CYP2C9MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |