Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 7/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | SIK1 | P57059 | 1/20 | 0.40 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57014 | 0.83 | NTRK1 (0.55) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3705688 | 0.83 | NTRK1 (0.59) | AURKAAURKBJAK2JAK3NTRK1 | |
| SCHEMBL27689864 | 0.80 | NTRK1 (0.61) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3698238 | 0.80 | NTRK1 (0.61) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3702483 | 0.79 | NTRK1 (0.58) | AURKAAURKBJAK2JAK3NTRK1 | |
| SCHEMBL4695227 | 0.74 | CCNT1 (0.47) | JAK2NTRK1ABL1FGFR1SRC | |
| SCHEMBL56315 | 0.73 | NTRK1 (0.59) | AURKAAURKBJAK2NTRK1ABL1 | |
| SCHEMBL3777718 | 0.71 | NTRK1 (0.77) | JAK2NTRK1ABL1FGRFGFR1 | |
| Azd-7451 SCHEMBL3769178 | 0.70 | NTRK1 (0.76) | JAK2NTRK1ABL1FGRFGFR1 | |
| Azd-7451 SCHEMBL18797141 | 0.70 | NTRK1 (0.76) | JAK2NTRK1ABL1FGRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |